Allergy

CURAX also offers models in which immune responses against allergens can be tested. One commonly-used allergen is the chicken protein ovalbumin. CURAX also offers models that enable you to study allergic reactions against peanut and cows’ milk proteins.

Animal models:
Ovalbumin-induced allergy
Peanut-induced allergy
Cows’ milk protein induced allergy

Outcome:
Allergen-specific cellular responses
Cytokines & other mediators
Allergen-specific antibody titres
Allergen-specific clinical symptoms:
Immediate skin reaction
Gastrointestinal tract responsiveness in vitro and ex vivo

Literature:

1) van Wijk et al. CTLA-4 Signaling Regulates the Intensity of Hypersensitivity Responses to Food Antigens, but is Not Decisive in the Induction of Sensitization, The Journal of Immunology, 2005, 174: 174–179.

2) Ruiter et al. Characterization of T cell epitopes in as1-casein in cow’s milk allergic, atopic and non-atopic children, Clinical and Experimental Allergy, 2006, 36, 303–310

3) A. H. van Houwelingen et al. Topical application of F991, an immunoglobulin free light chain antagonist, prevents development of contact sensitivity in mice, Clinical and Experimental Allergy, 2007, 37, 270–275