Asthma

Asthma

As is commonly known, the allergic response to ovalbumin is also used to study asthmatic reactions in animals. CURAX is specialised in measuring respiratory tract function in several ways and in a variety of models. These models include both allergic and non-allergic asthma models. Depending on the research question mice, rats and/or guinea pigs are used.

Asthma models:
Ovalbumin-induced acute and chronic allergic asthma
Dinitrofluorobenzene-induced occupational asthma
Virus induced asthma

Outcome:
Early and Late Asthmatic Reactions
Airway responsiveness in vitro and in vivo
Isolated perfused lung
Airway inflammation and damage
Cytokines & inflammatory mediators
Immuneglobulins

Literature:

1) Verheijden et al. The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V. Eur J Nutr. 2015, 24. 

 

 

2) Verheijden et al., Dietary galacto-oligosaccharides prevent airway eosinophilia and hyperresponsiveness in a murine house dust mite-induced asthma model. Respir Res. 2015;16:17. 

 

 

3) Sagar et al., Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma. Respir Res. 2014;15:46.