As is commonly known, the allergic response to ovalbumin is also used to study asthmatic reactions in animals. CURAX is specialised in measuring respiratory tract function in several ways and in a variety of models. These models include both allergic and non-allergic asthma models. Depending on the research question mice, rats and/or guinea pigs are used.
Ovalbumin-induced acute and chronic allergic asthma
Dinitrofluorobenzene-induced occupational asthma
Virus induced asthma
Early and Late Asthmatic Reactions
Airway responsiveness in vitro and in vivo
Isolated perfused lung
Airway inflammation and damage
Cytokines & inflammatory mediators
1) Verheijden et al. The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V. Eur J Nutr. 2015, 24.
2) Verheijden et al., Dietary galacto-oligosaccharides prevent airway eosinophilia and hyperresponsiveness in a murine house dust mite-induced asthma model. Respir Res. 2015;16:17.
3) Sagar et al., Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma. Respir Res. 2014;15:46.