Inflammatory Bowel Disease
Inflammatory bowel disease (IBD): CURAX also has know-how in measuring the physiological functioning of the gastro-intestinal tract. IBD, in particular has been an important topic of research.
IBD models in mice and rats:
Dextran Sulphate Salt induced Ulcerative Colitis
Dinitrofluorobenzene induced Crohn’s disease
Rectal bleeding score
Total clinical score
GI responsiveness in vitro and ex vivo
Cytokines & inflammatory mediators
1) Zheng et al., Bifidobacterium breve attenuates murine dextran sodium sulfate-induced colitis and increases regulatory T cell responses. PLoS One. 2014;9:e95441.
2) Zheng et al., Specific probiotic dietary supplementation leads to different effects during remission and relapse in murine chronic colitis. Benef Microbes. 2015 8:1-10.
3) Morgan et al., Toll-like receptor 6 stimulation promotes T-helper 1 and 17 responses in gastrointestinal-associated lymphoid tissue and modulates murine experimental colitis. Mucosal Immunol. 2014;7:1266-77.