Inflammatory Bowel Disease

Inflammatory Bowel Disease

Inflammatory bowel disease (IBD): CURAX also has know-how in measuring the physiological functioning of the gastro-intestinal tract. IBD, in particular has been an important topic of research.

IBD models in mice and rats:
Dextran Sulphate Salt induced Ulcerative Colitis
Dinitrofluorobenzene induced Crohn’s disease

Outcome:
Stool consistency
Rectal bleeding score
Total clinical score
Colon length
GI responsiveness in vitro and ex vivo
Histological score
Cytokines & inflammatory mediators
Micro-vascular permeability
Gastrointestinal inflammation

Literature:

 

1) Zheng et al., Bifidobacterium breve attenuates murine dextran sodium sulfate-induced colitis and increases regulatory T cell responses. PLoS One. 2014;9:e95441. 

 

2) Zheng et al., Specific probiotic dietary supplementation leads to  different effects during remission and relapse in murine chronic colitis. Benef Microbes. 2015 8:1-10. 

 

3) Morgan et al., Toll-like receptor 6 stimulation promotes T-helper 1 and 17 responses in gastrointestinal-associated lymphoid tissue and modulates murine experimental colitis. Mucosal Immunol. 2014;7:1266-77.